Discovery of 4H-1,2,4-Triazol-4-amine

The synthetic route of 584-13-4 has been constantly updated, and we look forward to future research findings.

584-13-4, name is 4H-1,2,4-Triazol-4-amine, belongs to triazoles compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 4H-1,2,4-Triazol-4-amine

1) 30 g of 5-bromomethyl-alpha, alpha, alpha ‘, alpha’-tetramethyl-1,3-benzenediacetonitrile was added successively to a glass reactor, 4-amino-1,2,4-triazole, acetonitrile 80 ml, heated to reflux under stirring, after 12 h, cooling, crystallization at 0 deg. 8h. Filtration, dried, to give 35.58 g of intermediate I, yield 93.0%;

The synthetic route of 584-13-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Yangtze River Pharmaceutical Group Jiangsu Haici Biological Pharmaceutical Co., Ltd.; Yangtze River Pharmaceutical Group Co., Ltd.; Niu, Mingyu; Ma, Lijin; Liang, Wen; Wang, Qinghui; Lu, Guihua; Lu, Tianyu; Wang, Wei; (8 pag.)CN106083748; (2016); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics