Electric Literature of 5232-99-5, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 5232-99-5, Name is Ethyl 2-cyano-3,3-diphenylacrylate, SMILES is CCOC(=O)C(C#N)=C(C1=CC=CC=C1)C1=CC=CC=C1, belongs to Triazoles compound. In a article, author is Kervefors, Gabriella, introduce new discover of the category.
Synthesis and Biological Studies of O3-Aryl Galactosides as Galectin Inhibitors
beta-Galactose derivatives have recently been reported to selectively inhibit galectin-3, and a library of O3-arylated galactosides with varying substitution patterns was designed to study such inhibitions further. The O3-arylated galactosides were synthesized using diaryliodonium salts under mild and transition metal free conditions, providing the target products in moderate to good yields. An O3-trifluoroethylated galactoside was also synthesized using iodonium salt chemistry. Azido-substituted products were subsequently transformed into the corresponding triazoles. After deprotection, a selection of galactoside derivatives were evaluated for inhibitory potencies against galectins-1, 3, 4 N (N-terminal domain), 4 C (C-terminal domain), 7, 8 N, 8 C, 9 N, and 9 C and one compound with promising affinity and selectivity for both the N- and C-terminal domain of galectin-9 was discovered.
Electric Literature of 5232-99-5, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 5232-99-5.