The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4-(4-Bromophenyl)-5-methylthiazol-2-amine(SMILESS: NC1=NC(C2=CC=C(Br)C=C2)=C(C)S1,cas:65705-44-4) is researched.Electric Literature of C4H7BrO2. The article 《Discovery of thiazolyl-phthalazinone acetamides as potent glucose uptake activators via high-throughput screening》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:65705-44-4).
With the aim to discover orally active small mols. that stimulate glucose uptake, high throughput screening of a library of 5000 drug-like compounds was conducted in differentiated skeletal muscle cells in presence of insulin. N-Substituted phthalazinone acetamide was identified as a potential glucose uptake modulator. Several novel derivatives were synthesized to establish structure activity relationships. Identified lead thiazolyl-phthalazinone acetamide (7114863; I) increased glucose uptake (EC50 of 0.07±0.02 μM) in differentiated skeletal muscle cells in presence of insulin. Furthermore, I was superior to rosiglitazone under similar exptl. conditions without inducing PPAR-γ agonist activity thus making it a very interesting scaffold.
In addition to the literature in the link below, there is a lot of literature about this compound(4-(4-Bromophenyl)-5-methylthiazol-2-amine)Product Details of 65705-44-4, illustrating the importance and wide applicability of this compound(65705-44-4).
Reference:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics