Related Products of 7170-01-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7170-01-6 as follows.
To a magnetically stirred solution of 2-(difluorom- ethyl)-i-fluoro-4-nitrobenzene (2 g, 10.47 mmol) in DMSO (10 mE) at 0 C. were added K2C03 (1.446 g, 10.47 mmol) and 3-methyl-1H-i,2,4-triazole (0.870 g, 10.47 mmol). The reaction mixture was allowed to warm to RT and stirred overnight, poured into ice and extracted with EtOAc (50 mE, twice). The combined organic layers were washed with brine, dried over Na2504, and concentrated under reduced pressure. The residue was purified on l3iotage using a 0-20% gradient of EtOAc in petroleum ethet Two sets of fractions with desired product mass were isolated, one of which was confirmed to be the desired nitro triazole product by x-ray crystal analysis. ?H NMR (400 MHz, CHEOROFORM-d) oe 400 MHz: 8.74-8.73 (1H, d, J=2.i Hz), 8.51-8.47 (1H, m),8.39 (1H, s), 7.70-7.67 (1H, d, J=8.4), 7.39-7.02 (1H, t, J=54), 2.53 (3H, s). ECMS M+H=255.2.
According to the analysis of related databases, 7170-01-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; MCDONALD, Ivar M.; SIVAPRAKASAM, Prasanna; IWUAGWU, Christiana I.; Peese, Kevin M.; CHENG, Heng; CHOWDARI, Naidu S.; GANGWAR, Sanjeev; (75 pag.)US2018/110873; (2018); A1;,
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