Synthetic Route of 6523-49-5, A common heterocyclic compound, 6523-49-5, name is 4-(1,2,4-Triazol-1-yl)aniline, molecular formula is C8H8N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE 2 Preparation of (3Z)-3-{[4-(1H-1,2,4-triazol-1-yl)anilino]-methylene}-1,3-dihydro-2H-indol-2-one Prepared in an analogous manner to Example 1 using 1 equivalent of 4-(1H-1,2,4-trizol-1-yl)aniline in place of 5-aminobenzimidazolone. 1H NMR (DMSO-d6): delta10.80 (m, 1H); 10.52 (s, 1H); 9.26 (s, 1H); 8.62 (m, 1H); 8.22 (s, 1H); 7.86 (m, 2H); 7.60 (m, 3H); 7.02 (m, 1H); 6.94 (m, 1H); 6.85 (m, 1H). APCI MS (+ve) 304. APCI MS (-ve) 302.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Harris, Philip Anthony; McNutt JR., Robert Walton; Kuyper, Lee Frederick; Lackey, Karen Elizabeth; Peel, Michael Robert; Wood III, Edgar Raymond; US2003/225090; (2003); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics