Recently I am researching about INSULIN-RESISTANCE; LIPID-METABOLISM; LIVER; SREBP-1C; LIPOGENESIS; PATHOGENESIS; EXPRESSION; METFORMIN; PROMOTER; PATHWAY, Saw an article supported by the IIT Mandi, Department of Biotechnology, India [BT/PR22214/NNT/28/1267/2017]; Science & Engineering Research Board grant, India [ECR/2015/000165]; UGC, IndiaUniversity Grants Commission, India. Published in ELSEVIER SCIENCE BV in AMSTERDAM ,Authors: Dogra, S; Kar, AK; Girdhar, K; Daniel, PV; Chatterjee, S; Choubey, A; Ghosh, S; Patnaik, S; Ghosh, D; Mondal, P. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine. Application In Synthesis of 1H-1,2,4-Triazol-5-amine
Insulin resistance is thought to be a common link between obesity and Non-Alcoholic Fatty Liver Disease (NAFLD). NAFLD has now reached epidemic status worldwide and identification of molecules or pathways as newer therapeutic strategies either to prevent or overcome insulin resistance seems critical. Dysregulated hepatic lipogenesis (DNL) is a hallmark of NAFLD in humans and rodents. Therefore, reducing DNL accretion may be critical in the development of therapeutics of NAFLD. In our in vivo model (high-fat-diet fed [HFD] obese mice) we found Zinc oxide nanoparticles (ZnO NPs) significantly decreased HFD-induced hepatic steatosis and peripheral insulin resistance. This protective mechanism of ZnO NPs was signaled through hepatic SIRT1-LKB1-AMPK which restricted SREBP-lc within the cytosol limiting its transcriptional ability and thereby ameliorating HFD mediated DNL. These observations indicate that ZnO NP can serve as a therapeutic strategy to improve the physiological homeostasis during obesity and its associated metabolic abnormalities. (C) 2019 Elsevier Inc. All rights reserved.
Application In Synthesis of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Dogra, S; Kar, AK; Girdhar, K; Daniel, PV; Chatterjee, S; Choubey, A; Ghosh, S; Patnaik, S; Ghosh, D; Mondal, P or concate me.
Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics