Dunn, G. L. published the artcileOrally active 7-phenylglycyl cephalosporins. Structure-activity studies related to cefatrizine (SK & F 60771), Application of Sodium 1,2,3-triazole-5-thiolate, the publication is Journal of Antibiotics (1976), 29(1), 65-80, database is CAplus and MEDLINE.
A series of 24 broad-spectrum 7-phenylglycyl cephalosporins with 3-heterocyclicthiomethyl substituents was prepared by displacing the 3-acetoxy group of 7-aminocephalosporanic acid [957-68-6] with an appropriate heterocyclic thiol, followed by acylation by the mixed anhydride method. The effects of benzene ring hydroxylation and 3-substituent variation on in vitro antibacterial activity, height and duration of mouse serum levels, and protection against bacterial infection in the mouse were examined The most active, cefatrizine (I) [51627-14-6], had in vitro and in vivo activities and serum levels significantly higher than obtained with cephalexin [15686-71-2] or cephaloglycin [3577-01-3].
Journal of Antibiotics published new progress about 59032-27-8. 59032-27-8 belongs to triazoles, auxiliary class Triazoles, name is Sodium 1,2,3-triazole-5-thiolate, and the molecular formula is C2H2N3NaS, Application of Sodium 1,2,3-triazole-5-thiolate.
Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics