Recommanded Product: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amineIn 2022 ,《Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides》 was published in RSC Chemical Biology. The article was written by Dysko, Anna; Baker, Ysobel R.; McClorey, Graham; Wood, Matthew J. A.; Fenner, Sabine; Williams, Glynn; El-Sagheer, Afaf; Brown, Tom. The article contains the following contents:
Oligonucleotides are rapidly emerging as powerful therapeutics for hard to treat diseases. Short single-stranded oligonucleotides can base pair with target RNA and alter gene expression, providing an attractive therapeutic approach at the genetic level. While conceptually appealing, oligonucleotides require chem. modification for clin. use. One emerging approach is to substitute the phosphodiester backbone with other chem. linkages such as triazole. The triazole linkage is inherently resistant to enzymic degradation, providing stability in vivo, and is uncharged, potentially improving cell-penetration and in vivo distribution. Triazole linkages, however, are known to reduce RNA target binding affinity. Here we show that by attaching pyrene or anthraquinone to the ribose sugar on the 5′-side of the triazole, it is possible to recover duplex stability and restore the splice switching ability of triazole-containing oligonucleotides. The results came from multiple reactions, including the reaction of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Recommanded Product: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)
Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Recommanded Product: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics