El-Faham, Ayman published the artcileCOMU: A Safer and More Effective Replacement for Benzotriazole-Based Uronium Coupling Reagents, Application In Synthesis of 1082951-62-9, the publication is Chemistry – A European Journal (2009), 15(37), 9404-9416, S9404/1-S9404/34, database is CAplus and MEDLINE.
The authors describe a new family of uronium-type coupling reagents that differ in their iminium moieties and leaving groups. The presence of the morpholino group in conjunction with an oxime derivative, especially Et 2-cyano-2-(hydroxyimino)acetate (Oxyma), had a marked influence on the solubilities, stabilities, and reactivities of the reagents. Finally, the new uronium salt I (COMU) derived from Oxyma performed extremely well in the presence of only 1 equiv of base, thereby confirming the effect of the hydrogen bond acceptor in the reaction. I also showed a less hazardous safety profile than the benzotriazole-based HDMA and HDMB, which exhibited unpredictable autocatalytic decompositions Furthermore, the Oxyma moiety contained in I suggests a lower risk of explosion than in the case of the benzotriazole derivatives
Chemistry – A European Journal published new progress about 1082951-62-9. 1082951-62-9 belongs to triazoles, auxiliary class Active Esterification, name is 5-Chloro-1-((dimethyliminio)(morpholino)methyl)-1H-benzo[d][1,2,3]triazole 3-oxide hexafluorophosphate(V), and the molecular formula is C13H17ClF6N5O2P, Application In Synthesis of 1082951-62-9.
Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics