Adding a certain compound to certain chemical reactions, such as: 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1001401-62-2, category: Triazoles
A solution of 4-(2,2-difluoroethoxy)-2-(((3R,6R)-6-methylpiperidin-3- yl)oxy)pyridine (33 mg, 0.1 1 mmol), 2-(2H-l,2,3-triazol-2-yl)benzoic acid (20 mg, 0.1 1 mmol), EtaOmicronBetaTau (1.6 mg, 0.01 1 mmol), and EDC (30 mg, 0.16 mmol) in DMF (1.1 ml) was treated with triethylamine (37 mu^, 0.26 mmol) and heated at 50 C overnight. Additional 2-(2H- 1,2,3 -triazol- 2-yl)benzoic acid (1.3 equiv.), EDC (1 equiv.), and triethylamine (1 equiv.) were added and heating continued overnight. The reaction was diluted with saturated, aqu. aHC03 and extra water, then extracted 2x with EtOAc. The combined organics were washed with brine, dried over Na2S04, filtered, and concentrated. The crude material was purified by silica gel gradient chromatography (0-40% EtOAc in hexanes), then further purified by reverse phase HPLC, providing the titled compound as a tacky solid. HRMS m/z (M+H) 444.1827 found, 444.1842 required.
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Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; SKUDLAREK, Jason, W.; WO2014/137883; (2014); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics