Synthetic Route of 16681-70-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below.
lH-l,2,3-triazole-4-carboxylic acid (3.8 mg, 34 muiotaetaomicron) was combined with HATU (12.9 mg, 34 muiotaetaomicron) in DMF (2 mL) and stirred at room temperature for 15 minutes. (1374) Compound 3 (60 mg, 137 muiotaetaomicron) and DIPEA (16 mu^, 92 muiotaetaomicron) were then added. The solution was stirred at room temperature for 15 minutes, at which time LCMS showed reaction completion. The solvent was removed in vacuo and the crude residue was purified by reverse phase chromatography to yield Compound b (18.5 mg) as a TFA salt. MS m/z [M+H]+ calc’d for C26H31CIF 5O4, 532.21 ; found 532.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-[1,2,3]Triazole-4-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; FLEURY, Melissa; BEAUSOLIEL, Anne-Marie; HUGHES, Adam D.; LONG, Daniel D.; WILTON, Donna A.A.; WO2015/116786; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics