81606-79-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 81606-79-3, name is 2-(1,2,4-Triazol-1-yl)acetonitrile, A new synthetic method of this compound is introduced below.
To the solution of 3-[2-[tert-butyl(dimethyl)silyl]oxyethyl]benzaldehyde (1223. OOmg, 4.62mmol) , Toluene (2.5mL), Triethylamine (L95mL, l3.87mmol) was added 2-(lH- l,2,4-Triazol-l-yl)acetonitrile (874.9lmg, 8.09mmol) . The resulted mixture was microwaved at 150 degrees for 3 h. LCMS was shown some product and still had some remained starting material. The reaction mixture was worked up with water (50 mL) and DCM (50 mL x 2). The organic layer was brined and dried with MgS04. The concentrated crude was purified by prep HPLC Shimadzu to obtain 3-[3-[2- [tert-butyl(dimethyl)silyl] oxycthy I ] phenyl ] -2-( 1 ,2,4-triazol- 1 -yl)prop-2-enenitrile ( 120.00mg) with 7.3 % yield. LC-MS m/z: 355[M+l]
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; PRINCIPIA BIOPHARMA INC.; LOU, Yan; OWENS, Timothy Duncan; BRAMELD, Kenneth Albert; GOLDSTEIN, David Michael; (171 pag.)WO2019/99576; (2019); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics