Synthetic Route of 20725-34-2,Some common heterocyclic compound, 20725-34-2, name is 1-(4-Bromophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid, molecular formula is C10H8BrN3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a solution of compound 7 (5 mmol) in POCl3(15 mL), a solution of compound 11 (5 mmol) in ethanol (25 mL) was added and the reaction mixture was heated under reflux for 14 h under anhydrous conditions. The solvent was distilled in vacuo, the residual mass was poured over crushed ice and the excess POCl3 was neutralized with 10% sodium bicarbonate solution. The solid thus separated was filtered, washed with 10% sodium bicarbonate solution and finally with water, dried and purified by recrystallization from ethanol to give pure compounds12a-j.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(4-Bromophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid, its application will become more common.
Reference:
Article; Sanjeeva Reddy; Vani Devi; Sunitha; Kalyani; Nagaraj; Indian Journal of Chemistry – Section B Organic and Medicinal Chemistry; vol. 55B; 5; (2016); p. 590 – 597;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics