6523-49-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6523-49-5, name is 4-(1,2,4-Triazol-1-yl)aniline, A new synthetic method of this compound is introduced below.
To a solution of Intermediate 18 (60mg, 0.18mmol) in acetic acid (ImI) was added 4- triazolylaniline (35mg, 0.22mmol) and the solution was stirred at 8O0C over 2 hours. LCMS analysis showed consumption of starting material. Reaction mixture was cooled and the excess acetic acid removed by evaporation under reduced pressure. The residues were treated with sat. aq. Sodium hydrogen carbonate until cessation of effervescence. The resulting precipitate was filtered and the solids obtained dried under vacuum. Purification by preparative chromatography furnished the desired compound as an off- white solid (18mg, 22%)1H NMR (D6-DMSO) 10.21 (IH, bs), 9.07 (IH, s), 8.57 (IH, s), 8.42 (IH, s), 8.04 (IH, s), 8.00 (IH, dd, J 8.75Hz, 1.5Hz), 7.90 (2H, d, J 9Hz), 7.72 (IH, s), 7.68 (2H, d, J 3.25Hz), 7.27 (2H, s), 6.96 (IH, d, J 9Hz), 4.53 (IH, quin, J 6Hz), 3.64 (3H, s), 1.12 (6H, d, J 6.25Hz) LC-MS rt 2.48 m/z 454 ES+
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ARROW THERAPEUTICS LIMITED; WO2007/80401; (2007); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics