Adding a certain compound to certain chemical reactions, such as: 4923-01-7, name is 5-Methyl-4H-1,2,4-triazol-3-amine, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4923-01-7, Application In Synthesis of 5-Methyl-4H-1,2,4-triazol-3-amine
2-(2,3-Dihydrobenzofuran-5-yl)-N-(3-methyl-1H-1,2,4-triazol-5-yl)thiazole-4- To a mixture of 2-(2,3-dihydro-l-benzoruran-5~yl)-l,3-thiazole-4-carboxylic acid (126 mg, 0.51 mmol), lH-l ,2,4-triazol-5-amine (50 mg, 0.51 mmol) and 2-(lH-benzotriazole-l-yl)- 1 ,1 ,3,3-tetramethyluroniurn hexafluorophosphate (HBTU) (120 mg, 0.32 mmol) under stirring and heating at 1 10 C 2 ml of dry pyridine were added. The mixture was heated at 110 C for 5 h, pyridine was evaporated, and the residue was diluted with an aqueous Na2C03 solution. The resulting precipitate was filtered off, dissolved in hot NN-dimethylformamide, settled by addition of EtOAc and hexane, filtered off and dried. The product was obtained as a light yellow solid (82 mg, 0.25 mmol, 49 % yield). NMR (400 MHz, OMSO-d6, CC14) delta ppm 2.29 (3 H, bs, CH3), 3.30 (2 H, t, CH2CH20), 4.64 (2 H, t, OCH2), 6.80 (1 H, d, CH-arom.), 7.82 (1 H, d, CH-arom.), 8.00 (1 H, s, CH-arom.), 8.31 (1 H, bs, CH-thiazol), 1 1.20 (1 H, bs, NH), 12.95 (1 H, bs, NH). LC/MS [M+H]+: 328.0
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Reference:
Patent; 4SC DISCOVERY GMBH; LEBAN, Johann; ZAJA, Mirko; WO2014/202638; (2014); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics