I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Synthesis, molecular docking and antimicrobial activity of new fused pyrimidine and pyridine derivatives published in 2020.0. Application In Synthesis of 1H-1,2,4-Triazol-5-amine, Reprint Addresses Radwan, MAA; Alshubramy, MA (corresponding author), Qassim Univ, Dept Chem, Collage Sci, Buraydah, Saudi Arabia.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine
Synthesis of some new heterocyclic ring systems incorporated pyrimidine and pyridine moieties starting from 1-(furan-2-yl)-3-(thiophen-2-yl) chalcone was achieved. The structure of the new compounds was interpreted by spectral studies and ESI-MS analysis. Antimicrobial investigations of the designated compounds were performed towards some harmful pathogenic microbes. Antimicrobial tests proved that compound 11 unveiled a greater antimicrobial activity than other designed compounds. Docking of compound 11 into active site of DNA gyrase B chain displayed binding-energy of -13.05 kJ mol(-1) and distance at 3.18 A degrees. Furthermore, docking investigation was approved for the goal compounds into DNA gyrase B chain and exhibiting binding energy extended from -13.05 to -20.48 kJ mol(-1).
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Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics