Related Products of 7343-34-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7343-34-2 name is 3,5-Dimethyl-4H-1,2,4-triazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
5-cWoro-3-(3,5-dimethyl-lH-l,2,4-triazol-l-yl)pyridazine (23-2): To a stirring solution of 3,5-dichloropyridazine (23-1, 5.00 g , 33.5 mmol, 1.0 eq.) in tetrahydrofuran (125 ml) at 0 ¡ãC was added cesium carbonate (17.7 g, 50.3 mmol, 1.5 eq.), followed by 3,5-dimethyl-lH-l,2,4~triazole (3.25 g, 33.5 mmol, 1.0 eq.) in tetrahydrofuran (125 mL) dropwise. The resulting reaction mixture was stirred for 1 hour at the same temperature and then warmed to room temperature and stirred for another 3 hours, then heated to 60 ¡ãC and stirred for 6 hours. The solvent was removed under reduced pressure and the residue was diluted with water (200 mL) and extracted with DCM (3 chi 80 mL). The combined organic layers were dried over Na2S04, filtered and concentrated. The residue was purified by silica gel column chromatography (70percent ethyl acetate in hexanes) to afford 5-chloro-3-(3,5-dimethyl-lH-l,2,4-triazol-l-yl)pyridazine (23-2) as a white solid. 1H NMR (300 MHz, CDC13) delta 9.11 (d, 1H, J= 2.1 Hz), 8.20 (d, 1H, J= 2.1 Hz), 2.96 (s, 3H), 2.43 (s, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dimethyl-4H-1,2,4-triazole, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SHARP & DOHME CORP.; COX, Christopher, D.; DUDKIN, Vadim, Y.; KIM, June, J.; KUDUK, Scott, D.; MCVEAN, Carol; REGER, Thomas; STEEN, Justin; STEELE, Thomas; WO2013/52526; (2013); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics