Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone, is researched, Molecular C10H7F2N3O, CAS is 86404-63-9, about Design and synthesis of new fluconazole analogues.Application of 86404-63-9.
We have synthesized new fluconazole analogs containing two different 1,2,3-triazole units in the side chain. The synthesis of new amide analogs using a variety of acids is also described. All the compounds showed very good antifungal activity. A hemolysis study of the most active compounds I and II showed that both compounds did not cause any hemolysis at the dilutions tested. These compounds did not exhibit any toxicity to L929 cells at MIC and lower concentrations In the docking study, the overall binding mode of I and II appeared to be reasonable and provided a good insight into the structural basis of inhibition of Candida albicans Cyp51 by these compounds
Different reactions of this compound(1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone)Application of 86404-63-9 require different conditions, so the reaction conditions are very important.
Reference:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics