Synthetic Route of 930-33-6, The chemical industry reduces the impact on the environment during synthesis 930-33-6, name is 1H-1,2,4-Triazol-3(2H)-one, I believe this compound will play a more active role in future production and life.
10118] 509 g (28.28 mol) of water are added with stirring to the solution of OTA obtained (in 98% sulfuric acid), followed by 213 g (3.38 mol) of concentrated nitric acid (98% by weight commercial nitric acid).10119] After introduction of the nitric acid, the medium is brought to 65 C. and left stirring at this temperature for 2 hours.10120] Samples are withdrawn in order to monitor the progression of the nitration (once the temperature of the reaction medium has reached 65 C.). Said samples are analyzed after external calibration (using a commercial ONTA). The results are shown in FIG. 4. It is seen that a very high yield can be obtained.10121] The following procedure was carried out for the recovery of the ONTA prepared.10122] The reaction medium is cooled to 10 C. (at expiration of the 2 hours). An amount of 293 g (16.28 mol) of water is then added while maintaining the temperature at 10C. The crystallized ONTA is then filtered off and then pulled dry on a Buechner filter.10123] The weight of wet ONTA recovered is 403 g.10124] The HPLC analysis (of the ONTA recovered) makes it possible to establish, afier external calibration (with commercial ONTA), a yield of 96% ofwet product (Ito the starting ATA).10125] The nature ofthe product obtained (ONTA) was also confirmed by ?3C NMR.j0126] ?3C NMR (DMSO, 100 MHz): 8 158.22 ppm (s), 13924 ppm (s).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-1,2,4-Triazol-3(2H)-one, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; HERAKLES; EURENCO; HERVE, Gregoire; JACOB, Guy; CAGNON, Guy; BOUCHEZ, Jean-Marc; (9 pag.)US2016/46588; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics