In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 930-33-6, name is 1H-1,2,4-Triazol-3(2H)-one belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 1H-1,2,4-Triazol-3(2H)-one
To a mixture of l,2-dihydro-5H-l,2,4-triazol-3-one (5.74 mmol) in toluene (70 ml), al- pha,alpha-diphenylbenzenemethanol (4.7 mmol) and p-toluenesulphonic acid (1.91 mmol) were added. The reaction was heated at reflux using a Dean-Stark separa- tor under Nitrogen atmosphere for 20 hours. The solution was cooled and quenched with 2 % of an aqueous solution of NaHCO3 and extracted with CH2Cl2 (3×100 ml). The organic layer was separated, dried (Na2SO4) and the solvent evaporated. The resi- due was purified by column chromatography (eluent: CH2Cl2/Me0H 9/1). Yield: 925 mg of intermediate compound 26 (60 %).
The synthetic route of 930-33-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2006/67139; (2006); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics