Some common heterocyclic compound, 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, molecular formula is C9H7N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C9H7N3O2
2- (2H-1,2,3-triazol-2-yl) benzoic acid (0.37 g, 1.96 mmol)Was added to a 100 mL single-necked round bottom flask,Was dissolved in 20 mL of anhydrous dichloromethane, and then thionyl chloride (6 mL, 82.7 mmol) was added slowly,Pyridine (0.04 mL, 0.50 mmol) and gradually warmed to reflux for 3 hours.Stop the reaction, cool, and slowly evaporate the solvent, the product directly into the next step.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1001401-62-2, its application will become more common.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jin Chuanfei; Wei Dehuo; Xue Yaping; Zhang Yingjun; (44 pag.)CN106674207; (2017); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics