Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 151899-62-6, name is 3-Iodo-1-trityl-1H-1,2,4-triazole, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 3-Iodo-1-trityl-1H-1,2,4-triazole
Step 2: Preparation of 5-(3-chloro-4-fluorophenyl)-3-methyl-3-(pyrimidin-5-ylmethyl)-l-(l- trityl-l,2,4-triazol-3yl)-l,3-dihydro-2H-indol-2-oneTo 5-(3-chloro-4-fluorophenyl)-3-methyl- 1 -pyrimidin-2-yl- 1 ,3-dihydro-2H-indol-2-one (648 mg, 1.76 mmol), l-trityl-3-iodo-l,2,4-triazole (809 mg, 1.85 mmol, prepared using similar procedures as described in US Pat. No. 5,393,732 incorporated herein by reference in its entirety. Potassium carbonate (1071 mg, 7.75 mmol), N, N’-dimethylethylenediamine (0.300 mL, 2.82 mmol) and copper (I) iodide (268 mg, 1.41 mmol) under nitrogen was added toluene (15 mL).The mixture was stirred at 100 0C for 18 hours. The mixture was cooled and the solvent was evaporated under reduced pressure. The residue was purified by column chromatography on silica gel Biotage 25S, eluting with 0-100% ethyl acetate/hexanes, to afford -(3-chloro-4- fluorophenyl)-3-methyl-l-pyrimidin-2-yl-l,3-dihydro-2H-indol-2-one as a white solid.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 151899-62-6.
Reference:
Patent; MERCK & CO., INC.; WO2009/45386; (2009); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics