Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 288-36-8, name is 1H-1,2,3-Triazole, This compound has unique chemical properties. The synthetic route is as follows., Safety of 1H-1,2,3-Triazole
j0294] To 3-bromo-6-methylpicolinonitrile (2.2 g, ii mmol) in DMF (28 mE) was added K2C03 (i .7 g, i2 mmol) and 2H-i,2,3-triazole (650 pL, ii mmol). The mixture was heated to iOO C. for 36 h, cooled to rt and extracted with EtOAc. The combined organics were dried (Na2504) and concentrated. Purification via silica gel chromatography (i 0- i 00% EtOAc in hexanes) gave the title compound (i g, 48%).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 288-36-8.
Reference:
Patent; Janssen Pharmaceutica NV; COATE, Heather R.; DVORAK, Curt A.; FITZGERALD, Anne E.; LEBOLD, Terry P.; PREVILLE, Cathy; SHIREMAN, Brock T.; (473 pag.)US2016/46640; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics