Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3222-47-7, is researched, Molecular C7H7NO2, about Escaping from flatland: Substituted bridged pyrrolidine fragments with inherent three-dimensional character, the main research direction is methanoproline 3D design synthesis mol structure computation drug candidate; drug discovery design photochem natural product methanopropline conformation; amide urea combinatorial library proline hydroxymethyl methoxymethyl carboxamido; photocycloaddition saponification reduction.Formula: C7H7NO2.
The pressure to deliver new medicines to the patient continues to grow along with increases in compound failure rate, thus putting the current R&D model at risk. Anal. has shown that increasing the three-dimensionality of potential drug candidates decreases the risk of failure and improves binding selectivity and frequency. For this reason many workers have taken a new look at the power of photochem. as a means to generate novel sp3 rich scaffolds for use in drug discovery programs. Here we report the design, synthesis, and computational structural anal. of a series of 2,4-methanoprolines having inherent 3D character (PMI and PBF scores) significantly higher than that of the broader AbbVie Rule of 3 (Ro3) collection.
This literature about this compound(3222-47-7)Formula: C7H7NO2has given us a lot of inspiration, and I hope that the research on this compound(6-Methylnicotinic acid) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics