Related Products of 41253-21-8, These common heterocyclic compound, 41253-21-8, name is Sodium 1,2,4-triazol-1-ide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The 2mmol 3b dissolved in 10mLDMF, to the reaction solution was added 10mmol triazole sodium salt compound 4 and 2mmol DMPU, heated to 100-110 C and stirred for 24 hours. The mixture was quenched with water (1.5 L) and extracted with dichloromethane (50 mL * 2). The dichloromethane phase was washed once with saturated brine (20 mL), dried over Na2SO4 and concentrated to give a yellow oil which was purified by silica gel column chromatography Yellow solid 5b, yield 51%, purity 96%.
Statistics shows that Sodium 1,2,4-triazol-1-ide is playing an increasingly important role. we look forward to future research findings about 41253-21-8.
Reference:
Patent; Gansu Haotian Chemical Technology Co., Ltd.; Wei Pengfei; Wang Ning; Feng Weiwei; Wang Shixiang; Zhu Yingpu; (8 pag.)CN106397417; (2017); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics