An article Unorthodox synthesis, biological activity and DFT studies of novel and multifunctionalized naphthoxocine derivatives WOS:000486203200030 published article about CHROMONE-3-CARBOXYLIC ACID; REGIOSELECTIVE ACCESS; REARRANGEMENT; (+)-LAURENCIN; CYCLIZATIONS; ANNULATION; FRAMEWORK; ETHERS in [Abozeid, Mohamed Ahmed; El-Sawi, Aya Atef; Elmorsy, Mohamed Ramadan; Abdel-Rahman, Abdel-Rahman Hassan; El-Desoky, El-Sayed Ibrahim] Mansoura Univ, Fac Sci, Dept Chem, Mansoura 35516, Egypt; [Abdelmoteleb, Mohamed] Univ Nebraska, Dept Food Sci & Technol, FARRP, Lincoln, NE 68583 USA; [Abdelmoteleb, Mohamed] Mansoura Univ, Fac Sci, Dept Bot, Mansoura 35516, Egypt in 2019.0, Cited 37.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Category: Triazoles
A new promising protocol has been developed for the synthesis of scarce oxocine derivatives 3a-e and 6 through addition of amine-based nucleophiles such as hydroxylamine hydrochloride, primary amine and hydrazide to chromonylidene benzothiazol-2-ylacetonitrile 2 in refluxing dioxane under metal free reaction conditions in moderate to good yields. Other nitrogen nucleophiles such as piperidine, hydrazine and thiosemicarbazide failed to afford the corresponding oxocinols, and instead pyridine derivatives 7, 8 and 10 were obtained exclusively. Predictive study for the biological activities using PASS (prediction of activity spectra for biologically active substances) online software showed optimistic activities for oxocinols 3a-e in the treatment of cancer, influenza A and microbial infections. Additionally, DFT studies of oxocine derivatives 3a-e and 6 indicated the presence of required thermodynamics parameters for the application in dye-sensitized solar cells (DSSCs).
Category: Triazoles. Welcome to talk about 61-82-5, If you have any questions, you can contact Abozeid, MA; El-Sawi, AA; Elmorsy, MR; Abdelmoteleb, M; Abdel-Rahman, ARH; El-Desoky, ESI or send Email.
Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
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