In 2019,Applied Organometallic Chemistry included an article by Fischer-Durand, Nathalie; Lizinska, Daria; Guerineau, Vincent; Rudolf, Bogna; Salmain, Michele. Reference of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine. The article was titled 《’Clickable’ cyclopentadienyl iron carbonyl complexes for bioorthogonal conjugation of mid-infrared labels to a model protein and PAMAM dendrimer》. The information in the text is summarized as follows:
Owing to the intrinsic limitations of the conventional bioconjugation methods involving native nucleophilic functions of proteins, authors sought to develop alternative approaches to introduce metallocarbonyl IR labels onto proteins on the basis of the [3 + 2] dipolar azide-alkyne cycloaddition (AAC). To this end, two cyclopentadienyl iron dicarbonyl (Fp) complexes carrying a terminal or a strained alkyne handle were synthesized. Their reactivity was examined towards a model protein and poly (amidoamine) (PAMAM) dendrimer, both carrying azido groups. While the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) proceeded smoothly with the terminal alkyne metallocarbonyl derivative, labeling by strain-promoted azide-alkyne cycloaddition (SPAAC) was less successful in terms of final coupling ratios. IR spectral characterization of the bioconjugates showed the presence of two bands in the 2000 cm-1 region, owing to the stretching vibration modes of the carbonyl ligands of the Fp entities. In the part of experimental materials, we found many familiar compounds, such as Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Reference of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)
Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Reference of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)aminePolytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics