Gao, Yijun published the artcileDesign and synthesis of fluconazole derivatives, Quality Control of 86386-77-8, the publication is Zhongguo Xinyao Zazhi (2012), 21(6), 681-685, 700, database is CAplus.
Fluconazole derivatives I [wherein R = cyclopropyl, 1-Bu, 1-Pr, allyl, propargyl, iso-Bu, cyclopentyl, iso-Pr, Et, 1-pentyl, 1-hexyl, cyclohexyl, or benzyl] were designed and synthesized. Based on the previous result of computer-aided drug design, we systematically altered the structure of fluconazole according to the structure-activity relationships of the azoles in antifungal compounds and synthesized target compounds in six steps. Thirteen new compounds were synthesized. The structures were confirmed by 1H-NMR and MS. The design of synthetic route is reasonable. Target compounds are correct and can be used for further study of pharmacol. activities.
Zhongguo Xinyao Zazhi published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C12H13F2N3O4S, Quality Control of 86386-77-8.
Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics