On January 14, 2015, Goodman, C. Guy; Walker, Morgan M.; Johnson, Jeffrey S. published an article.Computed Properties of 1469801-67-9 The title of the article was Enantioconvergent Synthesis of Functionalized γ-Butyrolactones via (3 + 2)-Annulation. And the article contained the following:
A dynamic kinetic resolution of β-halo α-keto esters, RO2CC(:O)CHXR’ [R = Me, Bu-t, R’ = CH2Ph, X = Cl; R = Bu-t, R’ = Ph, Me, CH2CH2Me, CH2CCSiMe3, (CH2)3OCH2Ph; R = Bu-t, R’ = Ph, X = F] in an asym. homoenolate reaction is described. A chiral N-hetereocyclic carbene catalyzes the a3 → d3-umpolung addition of α,β-enals to racemic α-keto esters, forming γ-butyrolactones I [R1 = Ph, C6H4OMe-4, C6H4Cl-4, C6H4Me-4, C6H4Me-3, thien-2-yl, furan-2-yl, CH:CHPh-(E), CO3Et] and II [R2 = Ph, Me, CH2CH:CH2, CH2CCSiMe3, (CH2)3OCH2Ph, X = Cl; R = Ph, X = F] with three contiguous stereocenters. The addition occurs with high regio-, diastereo-, and enantiocontrol. This methodol. constitutes an intermol. DKR process to set three stereocenters during the key bond forming event. The experimental process involved the reaction of (R)-5-Benzyl-2-mesityl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate(cas: 1469801-67-9).Computed Properties of 1469801-67-9
The Article related to butyrolactone gamma derivative enantioconvergent annulation synthesis, halo keto ester dynamic kinetic resolution asym homoenolate reaction, alkenal annulation halo keto ester hetereocyclic carbene catalyst, regioselective annulation halo keto ester alkenal hetereocyclic carbene catalyst and other aspects.Computed Properties of 1469801-67-9
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics