《Expanding the Rubterolone Family: Intrinsic Reactivity and Directed Diversification of PKS-derived Pyrans》 was written by Guo, Huijuan; Benndorf, Rene; Koenig, Stefanie; Leichnitz, Daniel; Weigel, Christiane; Peschel, Gundela; Berthel, Patrick; Kaiser, Marcel; Steinbeck, Christoph; Werz, Oliver; Poulsen, Michael; Beemelmanns, Christine. Quality Control of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amineThis research focused ontropolone alkaloid biosynthesis antimicrobial cytotoxic antiinflammatory antiparasitic activity; biosynthetic pathway; chemical probes; natural products; polyketides; tropolone alkaloids. The article conveys some information:
We characterized two key biosynthetic intermediates of the intriguing rubterolone family (tropolone alkaloids) that contain a highly reactive pyran moiety (in equilibrium with the hydrolyzed 1,5-dione form) and undergo spontaneous pyridine formation in the presence of primary amines. We exploited the intrinsic reactivity of the pyran moiety and isolated several new rubterolone derivatives, two of which contain a unique thiazolidine moiety, e.g., I. Three rubterolone derivatives were chem. modified with fluorescence and biotin tags using peptide coupling and click reaction. Overall, eight derivatives were fully characterized by HRMS/MS and 1D and 2D NMR spectroscopy and their antimicrobial, cytotoxic, anti-inflammatory and antiparasitic activities evaluated. In addition to this study using Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine, there are many other studies that have used Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Quality Control of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine) was used in this study.
Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Quality Control of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics