Hadidi, Kaivin; Bellucci, Maria Cristina; Dall’Angelo, Sergio; Leeson-Payne, Alasdair; Rochford, Justin J.; Esko, Jeffery D.; Tor, Yitzhak; Volonterio, Alessandro published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《Guanidinoneomycin-maleimide molecular transporter: synthesis, chemistry and cellular uptake》.Product Details of 510758-28-8 The article contains the following contents:
Guanidino-glycosides are a class of non-cytotoxic mol. transporters capable of delivering high mol. weight bioactive cargos into cells at low nanomolar concentrations Efficient bioconjugation with guanidinoglycosides has been previously demonstrated by utilizing a guanidinoneomycin decorated with a reactive but also unstable N-hydroxysuccinimmide ester-containing linker. Herein we report the synthesis, chem., and application of a new, stable guanidinoneomycin derivative armed with a highly specific maleimide moiety which allows for thiol-maleimide click chem., a highly popular bioconjugation strategy, widening the field of application of these intriguing and useful delivery vehicles. In the experimental materials used by the author, we found Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Product Details of 510758-28-8)
Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Product Details of 510758-28-8Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics