Thermodynamics of proton ionization from some substituted 1,2,3-triazoles in dilute aqueous solution was written by Hansen, Lee Duane;West, Bruce David;Baca, Ernest J.;Blank, Clarence L.. And the article was included in Journal of the American Chemical Society in 1968.Electric Literature of C4H3N3O4 This article mentions the following:
The ΔH°, ΔS°, and pK values valid at 25° and zero ionic strength are reported for 1,2,3-triazole, 4,5-dibromo-1,2,3-triazole, 1,2,3-triazole-4-carboxylic acid, 1,2,3-triazole-4,5-dicarboxylic acid, benzotriazole, 1-phenyl-1,2,3-triazole-4-carboxylic acid, 1-phenyl-1,2,3-triazole-4,5-dicarboxylic acid, and 1-phenyl-5-methyl-1,2,3-triazole-4-carboxylic acid. Unusual substitution effects on the thermodynamics of proton ionization from the triazole ring are found. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Electric Literature of C4H3N3O4).
1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.Electric Literature of C4H3N3O4
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics