《High-yield synthesis of oligoribonucleotides using o-nitrobenzyl protection of 2′-hydroxyls》 was written by Hayes, J. A.; Brunden, M. J.; Gilham, P. T.; Gough, G. R.. Application In Synthesis of 3-Nitro-1-tosyl-1H-1,2,4-triazole And the article was included in Tetrahedron Letters in 1985. The article conveys some information:
Use of published procedures for photolytic removal of 2′-O-(o-nitrobenzyl) substituents from model oligoribonucleotides results in low yields of fully-deprotected products accompanied by significant amounts of oligomers carrying altered, UV light-resistant residues derived from the 2′-blocking groups. The efficiency of the deprotection has depends on pH; the side-reactions are avoided when the photolysis is carried out in solution buffered at pH 3.5. In the experiment, the researchers used many compounds, for example, 3-Nitro-1-tosyl-1H-1,2,4-triazole(cas: 77451-51-5Application In Synthesis of 3-Nitro-1-tosyl-1H-1,2,4-triazole)
3-Nitro-1-tosyl-1H-1,2,4-triazole(cas: 77451-51-5) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Application In Synthesis of 3-Nitro-1-tosyl-1H-1,2,4-triazole
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics