Hu, Xiaoyan published the artcileSynthesis and antifungal activity of triazole derivatives, Recommanded Product: 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, the publication is Huaxue Yanjiu Yu Yingyong (2010), 22(12), 1573-1577, database is CAplus.
To study the antifungal mechanism and structure-activity relationship of the azole compounds, four triazole compounds were designed and synthesized. The said triazole derivatives, e.g., I, were prepared via Friedel-Crafts acetylation of 1,3-difluorobenzene with chloroacetyl chloride; the resulting α-chloro-2,4-difluoroacetophenone underwent condensation with 1,2,4-triazole to give α-(1,2,4-triazol-1-yl)-2,4-difluoroacetophenone, which underwent cyclization to give 1-[2-(2,4-difluorophenyl)-1,2-epoxy-3-propyl]-1H-1,2,4-triazole, which underwent additive ring-opening with Et 1-piperazinecarboxylate to give 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-(4-ethoxycarbonylpiperazin-1-yl)propan-2-ol, which underwent hydrolysis to give 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-(piperazin-1-yl)propan-2-ol, which underwent N-alkylation with alkyl halides to give the title compounds All of them were confirmed by 1H-NMR and MS spectra. Antifungal activities of title compounds were evaluated. And the results of the preliminary antifungal test showed that all compounds exhibited inhibitory effects on C. albicans and C. neoformans. Two of the compounds showed higher activity than fluconazole.
Huaxue Yanjiu Yu Yingyong published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C12H13F2N3O4S, Recommanded Product: 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate.
Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics