Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 86404-63-9, is researched, SMILESS is FC1=CC=C(C(CN2N=CN=C2)=O)C(F)=C1, Molecular C10H7F2N3OJournal, Bioorganic & Medicinal Chemistry Letters called Novel antifungal 2-aryl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol derivatives with high activity against Aspergillus fumigatus, Author is Dickinson, Roger P.; Bell, Andrew S.; Hitchcock, Christopher A.; Narayanaswami, Subramaniyan; Ray, Stephen J.; Richardson, Kenneth; Troke, Peter F., the main research direction is aryltriazolylbutanol preparation fungicide; triazolylbutanol aryl preparation fungicide; voriconazole preparation fungicide.Category: triazoles.
Replacement of one triazole ring of fluconazole with 4-pyridinyl leads to an increase in activity against Aspergillus fumigatus. Introduction of an α-Me group has a marked addnl. beneficial effect. Investigation of pyridinyl and pyrimidinyl analogs resulted in the identification of compound I (UK-109,496, voriconazole) which has excellent potency against a broad range of fungal pathogens including A. fumigatus and Candida krusei.
After consulting a lot of data, we found that this compound(86404-63-9)Category: triazoles can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics