Introduction of a new synthetic route about 2-(2H-1,2,3-Triazol-2-yl)benzoic acid

The catalyzed pathway has a lower Ea, but the net change in energy that results from the reaction is not affected by the presence of a catalyst. In my other articles, you can also check out more blogs about 1001401-62-2

Research speed reading in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 2-(2H-1,2,3-Triazol-2-yl)benzoic acid

A solution of (3S,6R)-6-methylpiperidin-3-ol (2.36 g, 20.5 mmol), 2-(2H- 1,2,3- triazol-2-yl)benzoic acid (4.65 g, 24.6 mmol), EDC (7.86 g, 41.0 mmol), l-hydroxy-7- azabenzotriazole (5.58 g, 41.0 mmol), and triethylamine (8.57 mL, 61.5 mmol) in DMF (130 mL) was stirred at 50 C overnight, then diluted with saturated aqueous sodium bicarbonate and extracted 5x with ethyl acetate. The organics were washed with brine, dried over magnesium sulfate, filtered, and concentrated. The crude material was purified by silica gel gradient chromatography (0-100% ethyl acetate in hexanes), providing the titled compound as a peach- colored solid. LRMS m/z (Mu+Eta) 287.4 found, 287.1 required.

The catalyzed pathway has a lower Ea, but the net change in energy that results from the reaction is not affected by the presence of a catalyst. In my other articles, you can also check out more blogs about 1001401-62-2

Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; SKUDLAREK, Jason, W.; WO2015/95108; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics