Reference of 27808-16-8,Some common heterocyclic compound, 27808-16-8, name is 4-Methyl-1H-1,2,3-triazole, molecular formula is C3H5N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Intermediate 22: 1- (2-Fluoro-4-nitro-phenyl)-4-methvl-1, 2, 31-triazole; A mixture of 4-methyl- [1, 2,3]-triazole (60 g, 0.72 mol), K2HP04 (250 g, 1.44 mol) and 3,4- difluoronitrobenzene (80 ml, 0.723 mol) in DMF (3.4 litres) was stirred at 85C under N2 for 2.5 days. After removal of DMF in vacuo, the residue was chromatographed on silica gel with 0-5% ethyl acetate in dichloromethane to give the title compound as a light yellow solid (38.3 g, 24%). The other two isomers were also isolated. 1H-NMR (CDCl3) No. _5 : 8 8.35 (m, 1H) ; 8.23 (m, 2H); 7.98 (dd, 1H); 2.48 (d, 3H)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Methyl-1H-1,2,3-triazole, its application will become more common.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2003/72575; (2003); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics