Some common heterocyclic compound, 288-36-8, name is 1H-1,2,3-Triazole, molecular formula is C2H3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: Triazoles
To 2H-I,2,3-triazoe (2.0 g, 29 rnmo) n DMF (145 mL) was added NaH (116 g, 29 mmo, 60/b n mnera o) at RT and the mixture was sfirred for lh. After coohng to 0C, 2-choro-I-fluoro-4-ntrobenzene (4.6 g, 26.1 rnmo) was added and the reacUon mixture was stirred at 0C for l.5h, then at RT for I.5h. The mixture was quenched with water and extracted with AcOEt, The organic phase was washed with water and brine, dried over Na2SO4, fitered and concentrated. The crude product was purified by sihca g& co?umn (heptane/AcOEt: 90/10 to 50/50) to afford 2-(2-choro-4-nitropheny)-2 H-. 1,2,3- triazoe. M/z = 225-227 [M+H]+, Rt = 095 mm (UPLC Method 83).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 288-36-8, its application will become more common.
Reference:
Patent; NOVARTIS AG; PISSOT SOLDERMANN, Carole; QUANCARD, Jean; SCHLAPBACH, Achim; SIMIC, Oliver; TINTELNOT-BLOMLEY, Marina; ZOLLER, Thomas; (161 pag.)WO2015/181747; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics