Introduction of a new synthetic route about 288-88-0

Statistics shows that 1H-1,2,4-Triazole is playing an increasingly important role. we look forward to future research findings about 288-88-0.

288-88-0, Name is 1H-1,2,4-Triazole, 288-88-0, belongs to Triazoles compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

Example 1; Preparation of l-(4-NitrophenylmethyI)-l,2,4-triazole (i); Preparation of sodium triazole dihydrate; Into a IOOL glass flask were charged 50L of isopropanol and 2.9kg of sodium hydroxide flakes. The reaction mass was heated to 70C. After maintaining for 30min at same temperature lH-l,2,4-triazole (5.0kg) was added to the reaction mass. The reaction mass was maintained at reflux temperature for lhr. Slowly cooled the reaction mass to 30C and maintained for 3hr. The reaction mass was filtered and the wet cake washed with 5L of isopropanol. The wet material was dried at 600C until a constant weight is reached. Yield of sodium 1,2,4-triazole is 6.5kg.

Statistics shows that 1H-1,2,4-Triazole is playing an increasingly important role. we look forward to future research findings about 288-88-0.

Reference:
Patent; NATCO PHARMA LIMITED; PULLA REDDY, Muddasani; SATYASRINIVAS, Hanumara; RADHARANI, Kagitha; VENKAIAH CHOWDARY, Nannapaneni; WO2006/137083; (2006); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics