3641-08-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3641-08-5 name is 2H-1,2,4-Triazole-3-carboxamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
PREPARATION 20 o CF3SO3Si(CH2CH3)3 0^Nv Jl 2,6-lutdine ^Nv Jl f /T NH2 *- f /r VSi(CH2CH3)3HN-N HN-N H1 ,2-dichloroethane500C N-(triethylsilyl)-7H-l,2,4-triazole-3-carboxamideA stirred mixture of l//-l,2,4-triazole-3-carboxamide (500 mg, 4.46 mmol) in 1,2-dichloroethane (4.46 mL) treated at room temperature with 2,6-lutidine (2.08 mL, 17.84 mmol) and triethylsilyl trifluoromethanesulfonate (3.03 mL, 13.38 mmol) and heated under a nitrogen atmosphere at 5O0C. After 4 hours of heating the reaction solution allowed to cool to room temperature and diluted with dichloromethane (25 mL), washed with water (25 mL), 0.5M hydrochloric acid (25 mL), water (25 mL), dried over MgSO4, filtered, and evaporated to solid. The solid was flash chromatographed (silica gel, 10-65% ethyl acetate:hexane) to give the product as a white solid (683 mg).1H NMR (CDCl3, 500MHz, ppm) 0.89 (q, J=8Hz, 6H, CH2), 1.03 (t, j=8 Hz, 9H, CH3), 6.77 (s, IH, NH), 8.63 (s, IH, triazole H-5).LC/MS m/z (positive ion scan) M+l= 227.20
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2H-1,2,4-Triazole-3-carboxamide, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SHARP & DOHME CORP.; GREENLEE, Mark, L.; WILKENING, Robert; APGAR, James; WILDONGER, Kenneth, James; MENG, Dongfang; PARKER, Dann, L.; WO2010/19203; (2010); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics