Introduction of a new synthetic route about 4H-1,2,4-Triazol-4-amine

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 584-13-4, and we look forward to future research findings.

Research speed reading in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 584-13-4, name is 4H-1,2,4-Triazol-4-amine belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C2H4N4

2.6 g (0.15 mol)4-aminotriazole and 13.5 g (0.05 mol)4,4′-dicyanodiphenylmethane (compound 4), 250 ml of acetonitrile was added and the temperature was refluxed for 24 h, Drop to room temperature, precipitate solid, filter, the resulting solid dissolved in 120ml of water, Add 12ml concentrated hydrochloric acid, stirring and dissolving. 5.0 g of sodium nitrite was dissolved in 40 ml of water and then added dropwise to the above reaction solution at 0-5 C. After dripping, the reaction temperature was allowed to react at 0-5 C for 6 h, Reaction end, dropping ammonia water adjusted pH = 7, The filter cake was washed with water and dried to give 12.6 g of the final product compound 5 (letrozole) in 88.7% yield.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 584-13-4, and we look forward to future research findings.

Reference:
Patent; Zhejiang University of Technology; ZHANG, Xingxian; LI, Pengcheng; Qi, Weipeng; ZHOU, Xinyu; ZHOU, Jinjin; (9 pag.)CN105801501; (2016); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics