Application of 68744-64-9, These common heterocyclic compound, 68744-64-9, name is 5-(Trifluoromethyl)-4H-1,2,4-triazole-3-thiol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
5-Trifluoromethyl-lH- (1, 2,4)-triazole-3-thiol (l. 0g), heptafluoro-l-iodopropane (3.5 g) and triethyl- amine (0.90 g) were stirred in DMF (10 ml) at 90 C for 24 hours. After cooling to room temperature, he reaction mixture was diluted with ethyl acetate and washed with water and saturated aqueous solution of sodium chloride. After drying the organic layer with magnesium sulfate, the solvent was distilled off under the reduced pressure to obtain 3-heptafluoropropylsulfanyl-5-trifluoro- methyl-lH- (1, 2,4)-triazole (0.70g).
The synthetic route of 68744-64-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER CROPSCIENCE AG; WO2005/95351; (2005); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics