Introduction of a new synthetic route about 7170-01-6

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3-Methyl-1H-1,2,4-triazole.

Adding some certain compound to certain chemical reactions, such as: 7170-01-6, name is 3-Methyl-1H-1,2,4-triazole, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7170-01-6. 7170-01-6

250A. 5-(3-Methyl-lH-l,2,4-triazol-l-yl)isoquinoline: A mixture of 5- bromoisoquinoline (0.500 g, 2.403 mmol), 3-methyl-lH-l,2,4-triazole (0.599 g, 7.21 mmol), K2C03 (0.996 g, 7.21 mmol), and Cul (0.458 g, 2.403 mmol) in MP (5.0 mL) was heated at 150 C overnight. The reaction mixture was cooled to room temperature, filtered through a plug of CELITE, filter cake washed with 10% MeOH/DCM, filtrate absorbed onto silica gel, purified by reverse phase prep. HPLC, and concentrated to give a white solid (80 mg, 16%). XH NMR (400MHz, methanol-d4) delta 9.43 (d, J = 0.7 Hz, 1H), 8.83 (s, 1H), 8.57 (d, J = 6.2 Hz, 1H), 8.35 (d, J = 8.4 Hz, 1H), 7.99 (dd, J = 7.3, 1.1 Hz, 1H), 7.90 – 7.81 (m, 2H), 2.55 (s, 3H) ppm. MS (ESI) m/z: 211 (M+H)+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3-Methyl-1H-1,2,4-triazole.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; PINTO, Donald J.P.; CLARK, Charles G.; SMITH, II, Leon M.; ORWAT, Michael J.; JEON, Yoon; CORTE, James R.; WO2014/160668; (2014); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics