Synthetic Route of 23579-79-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 23579-79-5 name is 3,5-Dibromo-1-methyl-1H-1,2,4-triazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Bis(triphenylphosphine)palladium (II) chloride (2.487 mg, 3.54 .mol) was added to astirred mixture of 3-(tributylstannyl)-7-(triisopropylsilyl)-[1,2,3]triazolo[1,5-a]pyridine(10, 100 mg, 0.18 mmol) and 3,5-dibromo-1-methyl-1H-1,2,4-triazole (42.7 mg, 0.18mmol) and lithium chloride (22.53 mg, 0.53 mmol) dissolved in DME (1 mL) anddegased and purged with argon. The resulting mixture was heated at 130 C for 35minutes in the microwave. The mixture was evaporated under reduce pressure and theresidue was purified by preparative HPLC using a Waters X-Bridge reverse-phasecolumn (C-18, 5 microns silica, 19 mm diameter, 100 mm length, flow rate of 40 ml /minute) and decreasingly polar mixtures of water (containing 0.2% ammoniumcarbonate) and acetonitrile as eluent. The fractions containing the desired compound wereevaporated to dryness to afford 3-(3-bromo-1-methyl-1H-1,2,4-triazol-5-yl)-7-(triisopropylsilyl)-[1,2,3]triazolo[1,5-a]pyridine (42.4 mg, 55%) as a white solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dibromo-1-methyl-1H-1,2,4-triazole, and friends who are interested can also refer to it.
Reference:
Article; Germain, Herve; Harris, Craig S.; Lebraud, Honorine; Tetrahedron Letters; vol. 52; 48; (2011); p. 6376 – 6378;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics