Synthetic Route of 1533519-85-5, New Advances in Chemical Research in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 1533519-85-5, name is Methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate, molecular formula is C18H17N3O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
The compound a1 (50 g, 147.3 mmol, 1.0 eq.) Was dissolved in 500 mL of acetone, stirred at 20 to 30 C, methyl bromoacetate (1473 mmol, 10 eq.) Was added and reacted for 12 hours. The reaction solution was concentrated to dryness , And the concentrate was recrystallized from ethyl acetate to obtain 56.4 g of the catalyst b1 in a yield of 77.8%.
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Reference:
Patent; Beijing Xin To Lead Pharmaceutical Co., Ltd.; Wang Hui; Zhen Zhibin; Zhang Xiang; (10 pag.)CN106916115; (2017); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics