In 2022,Keivanloo, Ali; Abbaspour, Sima; Sepehri, Saghi; Bakherad, Mohammad published an article in Polycyclic Aromatic Compounds. The title of the article was 《Synthesis, Antibacterial Activity and Molecular Docking Study of a Series of 1,3-Oxazole-Quinoxaline Amine Hybrids》.HPLC of Formula: 510758-28-8 The author mentioned the following in the article:
A series of 1,3-oxazole-quinoxaline amine hybrids I (R = -NHMe, -NHBn, morpholin-4-yl, etc.; X = H, Cl) were prepared successfully through a copper-free Sonogashira coupling followed by heteroannulation in a one-pot process. The reaction of benzoyl chlorides, prop-2-yn-1-amine, and 2-amine-substituted 3-chloroquinoxalines catalyzed by Pd(Ph3P)2Cl2 in the presence of tris(benzyltriazolylmethyl)amine (TBTA) as an efficient ligand in EtOH produced 1,3-oxazole-quinoxaline amine hybrids in high yields. All the synthesized 1,3-oxazole-quinoxaline amine hybrids were screened for antibacterial properties and were exposed to mol. docking studies. Mol. docking study manifested the possible binding mode of compounds with its bacterial target protein. The consequences of biol. activity and docking study disclosed that the increase of lipophilic and extra hydrogen bond characters are essential for suitable antibacterial activity. In the part of experimental materials, we found many familiar compounds, such as Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8HPLC of Formula: 510758-28-8)
Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.HPLC of Formula: 510758-28-8
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics