Synthesis of heterocyclic compounds. III. Aryl-1,2,4-triazoles was written by Khan, Misbahul Ain;Polya, J. B.. And the article was included in Revista Latinoamericana de Quimica in 1972.Safety of 2-(1,2,4-Triazol-1-yl)aniline The following contents are mentioned in the article:
The aryltriazoles I-III (R = H, o-, p-NO2, o-, m-, p-Ph) were prepared An RC6H4NHNH2 reacted with Me2NCH:NCH:N+Me2 Cl- to give I. RC6H4NH2 condensed with HCONHNHCHO to give II. The Gomberg-Bauchmann arylation reaction of III (R = NH2) gave III (R = Ph, o-NO2C6H4, p-NO2C6H4). This study involved multiple reactions and reactants, such as 2-(1,2,4-Triazol-1-yl)aniline (cas: 39876-84-1Safety of 2-(1,2,4-Triazol-1-yl)aniline).
2-(1,2,4-Triazol-1-yl)aniline (cas: 39876-84-1) belongs to triazole derivatives. The many free lone pairs in triazoles make them useful as coordination compounds, although not typically as haptic ligands. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Safety of 2-(1,2,4-Triazol-1-yl)aniline
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics