In 2015,Konno, Hiroyuki; Abumi, Kanako; Sasaki, Yasuhiro; Yano, Shigekazu; Nosaka, Kazuto published 《Structure activity relationship study of burkholdine analogues toward simple antifungal agents》.Bioorganic & Medicinal Chemistry Letters published the findings.COA of Formula: C12H22F6N6OP2 The information in the text is summarized as follows:
Cyclic and linear lipopeptides, burkholdine analogs, were synthesized by conventional Fmoc-SPPS (Fmoc = tert-butoxycarabonyle) and cyclization with DIPC/HOBt in the solution phase. Synthesized peptides were evaluated for antifungal activities with MIC values against Saccharomyces cerevisiae and Aspergillus oryzae. As a result, the stereochem. of the amino acid residues and sequences of burkholdine analogs exerted a significant influence on antifungal activities. In addition, we found a linear burkholdine analog with moderate antifungal activities. In the experimental materials used by the author, we found ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6COA of Formula: C12H22F6N6OP2)
((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is a peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.COA of Formula: C12H22F6N6OP2
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics