On February 9, 2011, Kuang, Chunxiang; Jiang, Yubo; Wei, Jian published a patent.Quality Control of 4-(p-Tolyl)-1H-1,2,3-triazole The title of the patent was Preparation of 4-aryl-1H-1,2,3-triazoles as indoleamine 2,3-dioxygenase inhibitors. And the patent contained the following:
The title compounds I (R = aryl), are prepared by cyclizing trans-RCHBrCHBrCO2H with NaN3 in DMSO in N2 ambient in the presence of CuI, Na ascorbate and CsCO3 in a tubular reactor at 105-115°C for 2-6 h, extracting with Et acetate, vacuum concentrating to obtain crude product; and purifying on chromatog. column with petroleum ether-Et acetate as eluent. The molar ratio of trans-RCHBrCHBrCO2H to NaN3, CuI, Na ascorbate, and CsCO3 is 1:1.0-1:3.0, 1:0.1-1:0.3, 1:0.2-1:0.6, and 1:2-1:4, resp. The invention has the advantages of easily available materials, low cost, simple operation, and suitability for large-scale production I can be used as indoleamine 2,3-dioxygenase inhibitors. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Quality Control of 4-(p-Tolyl)-1H-1,2,3-triazole
The Article related to triazole aryl preparation indoleamine dioxygenase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Quality Control of 4-(p-Tolyl)-1H-1,2,3-triazole
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics