On September 11, 2013, Kuang, Chunxiang; Yang, Qing; Lixin, Juanzi; Wang, Xun; Li, Yonggang published a patent.Electric Literature of 5301-96-2 The title of the patent was Method for synthesizing 1H-1,2,3-triazole compounds. And the patent contained the following:
The title method comprises the steps of: taking p-toluenesulfonyl azide, aryl acetylene, a catalyst, a ligand and a solvent as a reaction system, performing reaction at 20-30°C under magnetic stirring for 10-60 min, adding a small amount of water into the reaction solution, heating, carrying out reaction at 80-130°C under magnetic stirring for 1-20 h, cooling reaction solution to room temperature, extracting, washing the organic layer, drying, vacuum distilling to remove solvent and obtain crude product, and separating and purifying by column chromatog. to obtain the the title product. According to this invention, inexpensive and easily available p-toluenesulfonyl azide and aryl acetylene are used as substrates, and NH-1,2,3-triazole compound can be easily and effectively synthesized under catalyst action. The method has the advantages of mild reaction condition, short reaction time, high safety, convenient operation, high reaction efficiency and low catalyst cost, and has potential application value. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Electric Literature of 5301-96-2
The Article related to triazole preparation cyclization, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Electric Literature of 5301-96-2
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics